Acyclovir lung penetration
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Comparison Of New Topical Treatments For Herpes Labialis
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Species differences in the metabolism and
Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir. Thus, we believe that our findings have a more general application for acyclovir and valacyclovir treatment. Again, the CSF acyclovir level was essentially stable, while the concentration in serum fluctuated. However, another possibility is that the carboxy metabolite of acyclovir is responsible for the neurotoxicity A. Linear regression on the log concentration versus time was used to calculate the terminal elimination rate constant k el. The example of the acyclovir experience. One serum sample and one CSF sample could not be obtained and were missing for analysis. Monitoring the safety of antivirals. Rating neurologic impairment in multiple sclerosis. The limit of quantification was 0.
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High acyclovir levels are required for the treatment of severe CNS infections in order to increase the antiviral efficacy and broaden the antiviral spectrum. This assumption was supported by the consistency of stable acyclovir concentrations in the CSF at steady state both in the present study and in the previous study Acyclovir concentrations in serum and cerebrospinal fluid at steady state. Rating neurologic impairment in multiple sclerosis. A review of its pharmacodynamic properties and therapeutic efficacy. Although the risk for neurotoxicity is mainly associated with intravenous acyclovir administration 18 , 26 , 28 , these adverse effects have also occurred during oral treatment and especially in patients with renal failure 6 , 9 , 11 , 15 , The main purpose of the present study was to establish whether oral administration of valacyclovir at 1, mg three times a day t. Sampling was performed at steady state after administration of the last oral dose of valacyclovir at 1, mg t. The limit of quantification was 0. Analysis of the pharmacokinetic data for the population gave very similar mean values for CL and V. A dysfunction of the blood-CSF barrier, which is common during CNS infections, would then increase the risk for neurotoxicity. Although CSF was sampled only twice in the present study, we assumed that the acyclovir concentration was essentially unchanged during the entire 8-h observation time. Ten patients two men and eight women with clinically definite MS 17 with a relapsing-remitting course were enrolled in a 6-day open-label pharmacokinetic study of oral valacyclovir at 1, mg t. Open in a separate window. Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir.