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Pharmacol , , Tausch, L. One characteristic of the group is the availability of a broad variety of cell-free and cell-based assays for assessment of biological activities related to inflammation and cancer. J Med Chem , 51, Virtual screening using a combined ligand- and structure-based pharmacophore model for 5-lipoxygenase-activating protein FLAP inhibitors led to the identification of 1- 2-chlorobenzyl 1- 4-isobutylphenyl ethyl -1H-benzimidazole 7 as developable candidate. Big huge thanks to breedspecialist Stephen Goodwin, Lanola UK for honouring our sweet youngster and her wonderful movement. J Immunol , , Koen Augustyns Secretary Rasmus P. Selected recent papers. A molecular basis for the anti-inflammatory actions of the bioactive ingredients from frankincense Br. Uli Stilz President Gerhard F. The compounds of interest, provided and synthesized by collaborators, include diverse natural compound from plants, fungi and myxobacteria and semi-synthetic derivatives thereof but also series of compounds from synthetic origin. The computer-aided design, the isolation and synthesis of compounds is performed together with specialized collaborators world-wide. Particular focus is placed on sex differences in the biological regulation of drug targets and on the influence of sex and sex hormones on the pharmacology of bioactive compounds.
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