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Pharmacol , , Tausch, L. One characteristic of the group is the availability of a broad variety of cell-free and cell-based assays for assessment of biological activities related to inflammation and cancer. J Med Chem , 51, Virtual screening using a combined ligand- and structure-based pharmacophore model for 5-lipoxygenase-activating protein FLAP inhibitors led to the identification of 1- 2-chlorobenzyl 1- 4-isobutylphenyl ethyl -1H-benzimidazole 7 as developable candidate. Big huge thanks to breedspecialist Stephen Goodwin, Lanola UK for honouring our sweet youngster and her wonderful movement. J Immunol , , Koen Augustyns Secretary Rasmus P. Selected recent papers. A molecular basis for the anti-inflammatory actions of the bioactive ingredients from frankincense Br. Uli Stilz President Gerhard F. The compounds of interest, provided and synthesized by collaborators, include diverse natural compound from plants, fungi and myxobacteria and semi-synthetic derivatives thereof but also series of compounds from synthetic origin. The computer-aided design, the isolation and synthesis of compounds is performed together with specialized collaborators world-wide. Particular focus is placed on sex differences in the biological regulation of drug targets and on the influence of sex and sex hormones on the pharmacology of bioactive compounds.

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Description: J Med Chem , 51, Accordingly, we found that male sex due to higher testosterone suppresses leukotriene biosynthesis in vitro and in vivo by altering the subcellular localisation of 5-LO. Particular focus is placed on sex differences in the biological regulation of drug targets and on the influence of sex and sex hormones on the pharmacology of bioactive compounds. Also to the committee of the Club for such a lovely venue and organized show. The idea behind such pharmacological profiling is to obtain i selective and efficient enzymes inhibitors lacking the disadvantages of former drug candidates, ii effective anti-inflammatory agents with synergistic action against both prostaglandin E2 and leukotrienes, iii drugs with less side effects as compared to traditional NSAIDs. Big huge thanks to breedspecialist Stephen Goodwin, Lanola UK for honouring our sweet youngster and her wonderful movement. The compounds of interest, provided and synthesized by collaborators, include diverse natural compound from plants, fungi and myxobacteria and semi-synthetic derivatives thereof but also series of compounds from synthetic origin. In collaboration with others total syntheses of selected natural products e. Virtual screening using a combined ligand- and structure-based pharmacophore model for 5-lipoxygenase-activating protein FLAP inhibitors led to the identification of 1- 2-chlorobenzyl 1- 4-isobutylphenyl ethyl -1H-benzimidazole 7 as developable candidate. Koen Augustyns Secretary Rasmus P. Biochemical Pharmacol. Investigations of the molecular pharmacological profile of inhibitors are conducted that consider in-vivo relevant influences of their action.
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